ABSTRACT
Objective To discuss and analyze the serum epidemiological characteristics of hepatitis B among people in Jinan in order to formulate applicable community nursing measures to control hepatitis B. Methods The serum marker of hepatitis B was tested by enzyme-linked immunosorbent assay in 26756 serum samples by strict operation according to the kit introduction. The data were analyzed by SPSS 13.0 software. Results The positive rate of HBsAg was 7.39%, among which the positive rate of male was 8.81% and female 5.54%, which was lower than that of the male (P<0.01). The positive rate of people lower than 20 years old was lower than those of above 20 years old. The positive rate of male from 21 to 30 years old was lower than those from 41 to 50 years old (P<0.05). No difference was seen between people with different professionals. Conclusions Vaccine inoculation of hepatitis B for susceptible population combined with community health education about hepatitis B related knowledge and comprehensive nursing intervention proved to be the pivotal measures for the control and prevention of hepatitis B.
ABSTRACT
Objective To discuss hemorheologic changes and hepatic function in patients with chronic hepatitis B(CHB)and its correlation with HBV genotype.Methods Relative index of hemorheologic changes,ALT,HBV-DNA and HBV genotype were examined in 96 CHB patients and 24 healthy control people.The results underwent correlation analysis.Results Low-shear blood viscosity and RBC aggregation index were significantly higher in CHB patients than those in the healthy control people(P＜0.05).Low-shear blood viscosity and RBC aggregation index were significantly higher in CHB patients with abnormal ALT than those CHB patients with normal ALT and the healthy control people(P＜0.05).No statistical difference was seen when CHB patients with normal ALT were compared with the healthy control people and patients with positive HBV-DNA were compared with patients with nesative HBV-DNA(P＞0.05).No statistical difference was seen in hemorheologic changes in CHB patients with different genotype(P＞0.05).Conclusions Microcirculation disorder of CHB patients is correlated with damage degree of hepatic function.Hemorheologic changes are not correlated with HBV-DNA and HBV genotype,so it can be a relatively independent index for clinical evaluation of disease.